Abstract Congress Neuroimmunomodulation 2014
García-Martín M. 1-2, Vida C. 1, Limonche S. 2, Martinez R.3, Colmenares F. 2, De la Fuente M. 1
1 Department of Animal Physiology II. Faculty of Biology. Complutense University of Madrid, Madrid, Spain.2 UCM Group for the Study of Animal and Human Behaviour, Department of Psychobiology. Faculty of Psychology. Complutense University of Madrid, Madrid, Spain. 3 Departament of Methodology of Behavioral Sciences, Faculty of Psychology. Complutense University of Madrid, Madrid, Spain.
Clinical studies provide evidence that several personality traits are associated with changes in immune function, having both an important influence in the health. The aim of the present study was to examine the association between personality (the big five factors of personality and self-esteem), subjective well-being (life satisfaction) and the lymphoproliferation response in a sample of 114 young (20-30 years old) healthy human volunteers (56 women and 58 men). Personality traits were determined by means of the revised NEO Personality Inventory (NEO PI-R) and the Self-Concept (AF5) questionnaires, whereas subjective well-being was evaluated via the Satisfaction With Life Scale (SWLS). Peripheral blood mononuclear leukocytes were obtained to assess the lymphoproliferative response in basal conditions and in the presence of mitogens (phytohemaglutinine and lypopolisacharide). The results revealed that participants with a high proliferation (both basal and stimulated conditions) are those showed a decreased social anxiety and vulnerability, and an increased gregariosness, assertiveness, positive emotions, feelings, achievement striving, self discipline, physic self-esteem and life satisfaction. These findings show the existence of an association between personality, well-being and lymphoproliferation. Thus, both positive and negative emotions appear to play a role in immune function, from which positivity may be the more powerful factor.
Funding: MINECO (BFU2011-30336; PSI2011-29016-C02-01); RETICEF (RD12/0043/0018)-ISCIII-FEDER (UE); UCM-Research Group (910379ENEROINN).